TABLE 5.
Effect of fks1-2 mutation in S. cerevisiae on sensitivities of cells and glucan synthase to L-733560, papulacandin, and acidic terpenoidsa
| Compound | MY2141 (FKS1 FKS2)
|
MY2140 (fks1-2 FKS2)
|
||
|---|---|---|---|---|
| MIC (μg/ml) | IC50 (μg/ml) for GS | MIC (μg/ml) | IC50 (μg/ml) for GS | |
| L-733560 | 0.31 | 0.4 | 25.0 | 25.0 |
| Papulacandin | 5.0 | 3.0 | 25.0 | 50.0 |
| Enfumafungin | 0.16 | 3.0 | 2.5 | >50.0 |
| Ascosteroside | 10.0 | 10.0 | >100.0 | >100.0 |
| Ergokonin A | 5.0 | 4.0 | 50.0 | 30.0 |
| Arundifungin | 5.0 | 4.0 | 20.0 | >25.0 |
a
MICs were determined as described in Materials and Methods, and glucan synthase (GS) assays were performed using the Brij 35 conditions.