. Author manuscript; available in PMC: 2022 May 1.

Published in final edited form as: Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Oct 7;6(5):545–555. doi: 10.1016/j.bpsc.2020.09.015

Table 3.

Summary of ECs Showing Both Group Differences, Linear Relationship With at Least 1 of the 3 Negative Affect z Scores in Dataset 1, Dataset 2, and Dataset 1+2, and Linear Relationship With at Least 1 of the CU Measures in Dataset 2

EC	Results on EC	Found in
Right AMY → Left AMY	CU greater than control Across all participants (both CU and control participants) in each dataset, greater EC was associated with greater DEP z score and greater composite ANX/DEP z score	Dataset 1, dataset 2
Right AMY → Left AMY	Across all participants (both CU and control participants) in dataset 2, greater EC was associated with greater ANX z score	Dataset 2
Left INS → Left AMY	CU smaller than control Across all participants (both CU and control participants) in dataset 1, smaller EC was associated with smaller ANX z score	Dataset 1
ACC → Left AMY	CU greater than control Across all participants (both CU and control participants) in dataset 2, greater EC was also associated with greater DEP z score and greater composite ANX/DEP z score	Dataset 2
mPFC → Right INS	CU greater than control Across all participants (both CU and control participants) in dataset 2, greater EC was also associated with smaller ANX z score	Dataset 2

Dataset 1: n = 28 for CU group, n = 28 for control group, and n = 56 for both groups combined; dataset 2: n = 21 for CU group, n = 21 for control group, and n = 42 for both groups combined; dataset 1+2: n = 49 for CU group, n = 49 for control group, and n = 98 for both groups combined.

ACC, anterior cingulate cortex; AMY, amygdala; ANX, anxiety; CU, cannabis use; DEP, depression; EC, effective connectivity; INS, insula; mPFC, medial prefrontal cortex.