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. 2022 Mar 30;79(5):498–507. doi: 10.1001/jamapsychiatry.2022.0407

Figure 1. Study Workflow.

Figure 1.

Each panel contains data (cylinders) input into processes, resulting in associations (brackets). A, Cytokine–brain structure associations were investigated with mendelian randomization. B, Differential expression analysis was performed between the whole brain and brain regions with interleukin 6 (IL-6) associations. C, Differentially expressed genes were enriched for functional and disease characteristics. D, IL-6 was tested for protein interactions in the STRING protein-protein interaction database version 11 (STRING Consortium) with differentially expressed genes. SNV indicates single-nucleotide variant.