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. Author manuscript; available in PMC: 2022 Mar 31.
Published in final edited form as: J Med Chem. 2021 Apr 6;64(8):4913–4946. doi: 10.1021/acs.jmedchem.1c00019

Table 2.

Thiazole substitution SAR.

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a

IC50 values were determined utilizing the diaphorase and resazurin-coupled R132H and R132C mIDH1 assays (average of N = 3). IC50 values are reported only for compounds where ≥75% inhibition of enzyme activity was observed at the highest concentration tested (38 μM).