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. Author manuscript; available in PMC: 2022 Mar 31.
Published in final edited form as: J Med Chem. 2021 Apr 6;64(8):4913–4946. doi: 10.1021/acs.jmedchem.1c00019

Table 7.

Pyridinone 6-position SAR.

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a

IC50 values were determined utilizing the diaphorase and resazurin-coupled mIDH1 R132H and R132C assays. IC50 is reported for compounds with >75% inhibition at 38μM, the highest concentration tested.