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. 2022 Mar 23;47(5):97. doi: 10.3892/or.2022.8308

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Copyright: © Yu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — IFNγ represses SLC7A11 expression through the JAK/STAT pathway. (A) Representative western blots of SLC7A11 in NCI-H295R cells and (B) quantified results. (C) Reverse transcription-quantitative PCR analysis was performed to measure the mRNA expression of SLC7A11. (D) Representative images of immunofluorescence observed by confocal fluorescence microscopy, which confirm the expression of SLC7A11, and (E) quantification of the results. (F) Representative western blots and quantification of the results for (G) p-STAT1/STAT1, (H) p-STAT3/STAT3 and (I) IRF1. Values are expressed as the mean ± standard deviation (**P<0.01). SLC7A11, solute carrier family 7 member 11; p-STAT1, phosphorylated signal transducer and activator of transcription; IRF1, IFN regulatory factor 1.