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. 2022 Mar 26;10(9):2829–2835. doi: 10.12998/wjcc.v10.i9.2829

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

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Histological characteristics and immunohistochemical images of the described patient with sarcomatoid intrahepatic cholangiocarcinoma. A and B: The tumor consists of poorly differentiated intrahepatic cholangiocarcinoma (right) and spindle cells as the sarcomatoid component (left), which are intermingled (H&E stain, 40 × and 100 ×, respectively); C: Immunohistochemical staining showed sarcomatoid components stained with diffuse vimentin (vimentin staining, 200 ×); D: Immunohistochemistry showed positive expression of cytokeratin 19 (CK19) in cholangiocarcinoma cells (CK19 staining, 200 ×); E: Immunohistochemistry showed positive expression of pan-CK in cholangiocarcinoma cells (pan-CK staining, 200 ×); F: Immunohistochemistry showed negative expression of hepatocyte paraffin 1 (HepPar-1) in the cells (HepPar-1 staining, 200 ×). iCCA: Intrahepatic cholangiocarcinoma; H&E: Hematoxylin and eosin; CK19: Cytokeratin 19; pan-CK: Pan-cytokeratin; HepPar1: Hepatocyte paraffin 1.