Table 5.
Multivariate Model of Type 2 Diabetes Mellitus Incidence (Defined by Incident Antihyperglycemic Medication Prescription at 18 Months Postinitiation) by Integrase Strand Transfer Inhibitor Versus Nonintegrase Strand Transfer Inhibitor
Factor | HR | Standard error | 95% CI | p |
---|---|---|---|---|
InSTI use (vs. non-InSTI) | 1.30 | 0.76 | −0.19 to 2.80 | 0.73 |
ART initiation year 2010–2012 | 0.77 | 0.93 | −1.04 to 2.59 | 0.78 |
ART initiation year 2012–2014 | 1.44 | 0.79 | −0.11 to 2.98 | 0.65 |
ART initiation year 2014–2016 | 1.25 | 0.97 | −0.65 to 3.15 | 0.82 |
ART initiation year 2016–2018 | 2.66 | 1.14 | 0.43 to 4.88 | 0.39 |
Age at ART initiation | 1.03 | 0.02 | 0.99 to 1.07 | 0.19 |
Sex: female | 2.72 | 0.54 | 1.66 to 3.78 | 0.06 |
Race: white | 0.58 | 0.78 | −0.96 to 2.11 | 0.48 |
Ethnicity: Hispanic or Latinx | 1.42 | 0.62 | 0.21 to 2.63 | 0.57 |
NRTI backbone: TAF | 1.60 | 1.03 | −0.42 to 3.62 | 0.65 |
NRTI backbone: ABC | 2.67 | 0.72 | 1.26 to 4.08 | 0.17 |
NRTI backbone: other | 0.00 | 4,795.79 | −9,399.73 to 9,399.74 | 1.00 |
CD4 at ART initiation | 1.00 | 0.01 | 1.00 to 1.00 | 0.20 |
HIV-1 RNA viral load at ART initiation | 1.00 | 0.00 | 1.00 to 1.00 | 0.456 |
ABC, abacavir; TAF, tenofovir alafenamide.