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. 2022 Mar 17;9:799053. doi: 10.3389/fnut.2022.799053

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Copyright © 2022 Qiao, Wang, Wang, Han, Qi, Zhang, Liu and You.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Single-cell RNA sequencing of colon tissues. UMAP analyses of colon tissues (n = 5 for biologically independent BD5115 animals vs. n = 5 for SM animals) from the SM group and BD5115 group are shown in (A,B), respectively. UMAP clustering of all cells in the BD5115 and SM group after integration. Each color represent cells with a different sub-identity. (C) The proportions of different cell types in the colon tissues of mice in the SM group and BD5115 group. (D) LGR5 gene expression in the SM group and BD5115 group. (E) MAFF gene expression in the SM group and BD5115 group. (F) Heatmap showing the DEGs in Caco-2 cells treated with BD5115 metabolites.