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. 2022 Mar 17;13:841873. doi: 10.3389/fphar.2022.841873

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Copyright © 2022 Towers, Setaro and Lynch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of sex and dose on the number of infusions and fentanyl intake in female and male rats under extended-access conditions. Mean (±SEM) number of infusions for each of the 10 extended-access sessions (A) and fentanyl intake averaged across the extended-access period (μg/kg); (B) for females and males in the 0.25 (n = 8 males, n = 9 females), 0.75 (n = 8 males, n = 9 females), 1.5 (n = 8 males, n = 8 females), and 3.0 (n = 8 males, n = 7 females) dose (μg/kg) conditions. (*) Significant sex difference within the two lower doses. (+) Significant decrease from session 1. (^) Significant increase from session 2. (#) Significant difference between the two lowest and two highest doses in females. Significant difference from (@) 0.25, (!) 0.75, and (%) 1.5 μg/kg.