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. 2022 Mar 17;13:841873. doi: 10.3389/fphar.2022.841873

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Copyright © 2022 Towers, Setaro and Lynch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of sex and dose on binge fentanyl intake in female and male rats under extended-access conditions. Mean (±SEM) number of active trials for each of the 10 extended-access sessions (A) and binge fentanyl intake (μg/kg) in active trials across all extended-access session (B) for females and males within the 0.25 (n = 8 males, n = 9 females), 0.75 (n = 8 males, n = 9 females), 1.5 (n = 8 males, n = 8 females), and 3.0 (n = 8 males, n = 7 females) dose (μg/kg) conditions. (*) Significant sex difference within the two lower doses. (+) Significant decrease from session 1. (^) Significant increase from session 2. (#) Significant increase compared with 0.25 and 3.0 μg/kg. Significant difference from (@) 0.25, (!) 0.75, and (%) 1.5 μg/kg.