Figure 4.

Structural analysis of lymph node matrices and collagen scaffolds for 3D culture models. Scanning electron microscopy (SEM) images of lymph node (LN) matrix (extracellular matrix [ECM]) specimens obtained, as previously described,³² from one Hodgkin lymphoma (HL) patient (I-19032-16, A and B) or a non-neoplastic LN (I-19273-16, C). SEM of Avitene^TMUltrafoam Collagen sponges, at the indicated magnifications, embedded and processed as LN-ECM specimens (D and F). Arrows indicate matrix branches surrounding empty spaces. Magnifications and scale bars are reported in each panel.