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. 2022 Mar 17;13:841099. doi: 10.3389/fimmu.2022.841099

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Copyright © 2022 Wu, Li, Rendahl and Bhargava

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FCGR1A genotypes containing the rs587598788-c.845-17delTCTTTG (rs587598788Del) allele are significantly associated with low CD64 expressions. (A) Monocytes from rs587598788-c.845-23 (rs587598788In) homozygous donors (In/In) expressed significantly higher levels of CD64 than those from the combined rs587598788 heterozygous (In/Del) and rs587598788Del homozygous (Del/Del) donors (Mann-Whitney test P = 0.0136). (B) CD64 expression data from a replication cohort confirmed that rs587598788-In/In homozygous donors expressed significantly higher levels of CD64 than those from the combined rs587598788-In/Del heterozygous and Del/Del homozygous donors. (C) CD64 expression levels on monocytes were not significantly different between the SNV rs1050204-G/G homozygous donors (G/G, N = 207) and the combined rs1050204-G/A heterozygous and rs1050204-A/A homozygous donors (Mann-Whitney test P = 0.488).