Table 2.
Association of FCGRIA varaints with sarcoidosis susceptibility.
| Variant | Risk allele | Genotype Frequency (%) | Unadjusted* | Adjusted for age and sex* | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| P | PFDR | OR (95% CI) | P | PFDR | OR (95% CI) | |||||
| rs1848781 | C | C/C | C/G | G/G | ||||||
| Case (N = 670) | 1056 (78.8%) | 439 (65.5%) | 178 (26.6%) | 53 (7.9%) | 0.769 | 0.769 | 1.026 (0.867-1.214) | 0.747 | 0.747 | 1.030 (0.857-1.239) |
| Control (N = 669) | 1048 (78.3%) | 434 (64.9%) | 180 (26.9%) | 55 (8.2%) | ||||||
| rs587598788 | In | In/In | In/Del | Del/Del | ||||||
| Case (N = 670) | 1301 (97.1%) | 633 (47.2%) | 35 (2.6%) | 2 (0.1%) | 0.077 | 0.115 | 1.418 (0.959-2.096) | 0.074 | 0.111 | 1.431 (0.962-2.128) |
| Control (N = 669) | 1281 (95.7%) | 618 (46.2%) | 45 (3.4%) | 6 (0.4%) | ||||||
| rs1050204 | G | G/G | A/G | A/A | ||||||
| Case (N = 670) | 1122 (83.7%) | 474 (70.7%) | 174 (26.0%) | 22 (3.3%) | 0.044 | 0.115 | 1.217 (1.005-1.475) | 0.042 | 0.111 | 1.222 (1.007 -1.546) |
| Control (N = 669) | 1079 (80.6%) | 446 (66.7%) | 187 (28.0%) | 36 (5.4%) | ||||||
*Additive model was used to test mode of inheritance.