Table 4.
Association of FCGRIA variants with poor lung function among sarcoidosis patients.
| Variant | Risk allele | Genotype Frequency (%) | P* | PFDR* | OR (95% CI) | ||
|---|---|---|---|---|---|---|---|
| rs1848781 | G | C/C | C/G | G/G | |||
| rst_pfts+ (N = 113) | 70 (31.0%) | 58 (51.3%) | 40 (35.4%) | 15 (13.3%) | 0.001 | 0.016 | 1.695 (1.263-2.262) |
| rst_pfts- (N = 557) | 214 (19.2%) | 381 (68.4%) | 138 (24.8%) | 38 (6.8%) | |||
| rs587598788 | In | In/In | In/Del | Del/Del | |||
| rst_pfts+ (N = 113) | 222 (98.2%) | 110 (97.3%) | 2 (1.8%) | 1 (0.9%) | 0.384 | 0.384 | 1.800 (0.633-5.118) |
| rst_pfts- (N = 557) | 1079 (96.9%) | 523 (93.9%) | 33 (5.9%) | 1 (0.2%) | |||
| rs1050204 | A | G/G | A/G | A/A | |||
| rst_pfts+ (N = 113) | 48 (21.2%) | 71 (62.8%) | 36 (31.9%) | 6 (5.3%) | 0.035 | 0.263 | 1.471 (1.028-2.079) |
| rst_pfts- (N = 557) | 170 (15.3%) | 403 (72.4%) | 138 (24.8%) | 16 (2.9%) | |||
*Additive model was used to test mode of inheritance. rst_pfts: restriction on pulmonary function tests, rst_pfts positivity indicates a poor lung function.