TABLE 3.
MIC ranges for QC strains
Methodology and antifungal agent | MIC range (μg/ml) for:
|
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
C. krusei ATCC 6258
|
C. parapsilosis ATCC 22019
|
|||||||||
Referencea | MIC80
|
MIC50
|
Reference | MIC80
|
MIC50
|
|||||
Shaken | Static | Shaken | Static | Shaken | Static | Shaken | Static | |||
NCCLS M27A | ||||||||||
ABb | 0.5–2 | 1–2 | 1–1 | NDg | ND | 0.25–1 | 0.25–0.5 | 0.25–0.5 | ND | ND |
5Fc | 4–16 | 16–16 | 16–16 | 16–16 | 8–16 | 0.12–0.5 | 0.25–0.5 | 0.5–0.5 | 0.25–0.5 | 0.25–0.5 |
FZd | 16–64 | 32–32 | 32–32 | 32–32 | 32–32 | 2–8 | 2–4 | 2–4 | 2–2 | 1–1 |
IZe | 0.12–0.5 | 0.5–1 | 0.5–0.5 | 0.25–0.25 | 0.12–0.25 | 0.06–0.25 | 0.12–0.25 | 0.03–0.12 | 0.03–0.06 | 0.015–0.06 |
RPMI–2% glucose | ||||||||||
AB | NAf | 2–2 | 1–2 | ND | ND | NA | 1–1 | 1–1 | ND | ND |
5F | NA | 16–16 | 8–8 | 8–8 | 4–4 | NA | 1–1 | 0.5–1 | 0.5–1 | 0.25–0.5 |
FZ | NA | 64–64 | 64–128 | 64–64 | 64–64 | NA | 16–16 | 4–8 | 4–8 | 4–4 |
IZ | NA | 1–2 | 1–1 | 0.25–0.5 | 0.12–0.25 | NA | 0.12–0.5 | 0.5–0.5 | 0.12–0.25 | 0.25–0.5 |
BYNB | ||||||||||
AB | NA | 2–8 | 2–2 | ND | ND | NA | 2–4 | 2–2 | ND | ND |
5F | NA | 32–32 | 32–32 | 16–32 | 16–16 | NA | 0.5–1 | 0.12–0.5 | 0.5–0.5 | 0.12–0.25 |
FZ | NA | 128–128 | 64–128 | 64–128 | 64–64 | NA | 4–8 | 4–8 | 4–4 | 4–4 |
IZ | NA | 2–2 | 1–2 | 0.5–1 | 0.5–1 | NA | 0.5–1 | 0.5–1 | 0.5–0.5 | 0.25–0.5 |
Following the data published in reference 4 for macrodilution broth.
AB, amphotericin B.
5F, flucytosine.
FZ, fluconazole.
IZ, itraconazole.
NA, not available.
ND, not done.