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. 2022 Mar 17;13:831397. doi: 10.3389/fgene.2022.831397

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Copyright © 2022 Lv, Fang, Qi, Xu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IGF2BP1 is targeted and regulated by let-7c-5p. (A) Differentially expressed mRNAs in normal group and tumor group was analyzed and the result was displayed in the Volcano Plot, in which red represents upregulated mRNAs and green represents downregulated mRNAs. (B) Venn diagram depicted the intersection of predicted target mRNAs and differentially upregulated mRNAs. (C,D) Pearson correlation analysis on potential target mRNAs and let-7c-5p, and the correlation analysis between IGF2BP1 and HOXA11-AS. (E) The target binding sequence of let-7c-5p on IGF2BP1 3′UTR was predicted on starBase database. (F) The target binding relationship of let-7c-5p and IGF2BP1 identified by dual-luciferase reporter detection. (G) qRT-PCR assessed expression level of IGF2BP1 mRNA after transfection in each group. (H) The expression of IGF2BP1 protein in each group of cells was tested in Western blot assay; *p < 0.05.