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. 2022 Mar 17;9:817826. doi: 10.3389/fcvm.2022.817826

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Copyright © 2022 Meihandoest, Studt, Mendez, Alberio, Fontana, Wuillemin, Schmidt, Graf, Gerber, Amstutz, Bovet, Sauter, Asmis and Nagler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association of heparin-calibrated anti-Xa measurements with drug concentration in 845 patients taking rivaroxaban, apixaban, or edoxaban in clinical practice. Ultra-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to determine drug levels. Spearman’s correlation coefficient (r_s) was 0.97 for rivaroxaban (95% CI 0.97–0.98), 0.96 for apixaban (0.95–0.97), and 0.96 for edoxaban (0.94–0.99). The overall r_s was 0.97 (95% CI, 0.97–0.98).