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. 2022 Mar 17;9:817826. doi: 10.3389/fcvm.2022.817826

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Copyright © 2022 Meihandoest, Studt, Mendez, Alberio, Fontana, Wuillemin, Schmidt, Graf, Gerber, Amstutz, Bovet, Sauter, Asmis and Nagler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagnostic accuracy of a universal, heparin-calibrated anti-Xa assay for the measurement of rivaroxaban, apixaban, and edoxaban drug concentrations in clinical practice (derivation dataset; n = 422). (A) Receiver-operating characteristics curve (ROC) showing the diagnostic accuracy. The area under the ROC curve was 0.99 for all cut-offs. (B) Confusion matrices at each cut-off. Drug levels above 30 μg L^–1 were detected with a sensitivity of 96.9% (95% CI 94.3, 98.5; cut-off value 0.26 U mL^–1), drug levels above 50 μg L^–1 with a sensitivity of 95.2% (95% CI 92.0, 97.4; cut-off value 0.40), and drug levels above 100 μg L^–1 with a sensitivity of 96.2% (95% CI 92.4, 98.5; cut-off value 0.77). Specificities were 92.2% (85.1, 96.6), 90.6% (84.7, 94.8), 88.1% (83.3, 92.0), respectively.