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. 2022 Feb;101(2):68–77. doi: 10.1124/molpharm.121.000385

TABLE 1.

Summary of properties of PS and DHEAS.The table provides the desensitization time constants in the presence of 30 µM steroid (τdesensitization), results of fits of steroid concentration-response data to the Hill equation (IC50 and nH), and results of fits to Eq. 12 (K and e).

Parameter PS DHEAS
τdesensitization at 30 µM (s)
(control in same cells)
4.1 ± 0.4
(41 ± 12)
2.3 ± 0.8
(43 ± 12)
IC50,peak (µM) 0.26 ± 0.03 1.01 ± 0.12
nH,peak −0.73 ± 0.05 −0.81 ± 0.06
IC50,sustained (µM) 1.45 ± 0.26 11.4 ± 0.8
nH,sustained −0.90 ± 0.11 −1.51 ± 0.10
K (µM) 22.6 ± 3.6 336 ± 25
e 6.2 × 10−5 ± 3.3 × 10−5 6.2 × 10-5*

*Constrained as described in Results. The numbers of cells are provided in text.