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. 2022 Mar 30;12(3):49. doi: 10.1038/s41408-022-00650-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Screening of the CLL cohort for IGLV3-21^R110 via flow cytometry and confirmation of results by next-generation sequencing (NGS) of the B cell receptor light chain (LC) repertoire. B Mutational profile of IGLV3-21^R110 expressing CLL cases. C Analysis of the IGLV3-21 immune repertoire in patients with IGLV3-21^R110 expressing CLL. Frequencies of IGLV3-21^G110 and IGLV3-21^R110 sequencing reads are plotted. D Clonal distribution of the IGLV immune repertoire in 12 patients with IGLV3-21^R110 expressing CLL as well as 6 control cases with nonIGLV3-21^R110 expressing lambda CLL, kappa CLL or healthy donors (HD). One bubble represents one IGLV clone. The area size of the bubbles is proportional to the clonal frequency except for the main CLL clone which dominates the repertoires. Cases with diverging IGLJ in IGLV3-21^R110 bystander clones are marked with an asterisk (*).