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. 2022 Mar 30;9:120. doi: 10.1038/s41597-022-01242-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Experimental setup for following the functional development of human and rat networks on two different MEA well plate types. After human pluripotent stem cells (hPSCs) differentiated into cortical neurons, they were plated on CytoView MEA 12 and CytoView MEA 48 well plates. Rat embryonic cortical cells were plated on the same MEA well plate types in parallel. Regular timepoint recordings were obtained in CytoView MEA 12, which has 64 electrodes per well, and pharmacological experiments were performed on CytoView MEA 48, which has 16 electrodes per well. Measurement days in MEA are referred to as days in vitro (DIV). Pharma recordings were obtained at DIV 29 and DIV 22, when peak activity is commonly observed for in vitro human and rat neuronal networks, respectively.