Table 1.
Prostatic Cancer – Introductory Space – Time Models
| Parameter | Model | ||||
|---|---|---|---|---|---|
| Parameter | Estimate (C.I.) | P | Coefficient | Value | P-Value |
| Cannabis Alone | S.D. | 4.8855 | |||
| spreml(Cancer Rate ~ Cannabis) | Log.Lik | − 2104.454 | |||
| Cannabis | −3.34 (−4.54, − 2.15) | 4.36e-08 | phi | 1.799117 | 0.0003 |
| psi | 0.662222 | < 2.2e-16 | |||
| rho | −0.809768 | < 2.2e-16 | |||
| lambda | 0.902303 | < 2.2e-16 | |||
| THC Alone | S.D. | 5.0538 | |||
| spreml(Cancer Rate ~ THC exposure) | Log.Lik | − 2099.24 | |||
| THC exposure | −2.06 (− 2.59, − 1.52) | 4.48e-14 | phi | 1.968582 | 0.0021 |
| psi | 0.626775 | < 2.2e-16 | |||
| rho | −0.782918 | < 2.2e-16 | |||
| lambda | 0.887035 | < 2.2e-16 | |||
| Cannabigerol Alone | S.D. | 1.0251 | 4.9450 | ||
| spreml(Cancer Rate ~ Cannabigerol exposure) | Log.Lik | − 979.9955 | − 2106.9850 | ||
| Cannabigerol exposure | − 1.84 (− 2.58, − 1.1) | 1.01e-06 | phi | 1.864451 | 0.0020 |
| psi | 0.655393 | < 2.2e-16 | |||
| rho | −0.80251 | < 2.2e-16 | |||
| lambda | 0.906276 | < 2.2e-16 | |||
| Cannabidiol Alone | S.D. | 5.1501 | |||
| spreml(Cancer Rate ~ Cannabidiol exposure) | Log.Lik | − 2105.8960 | |||
| Cannabidiol exposure | 1.61 (0.99, 2.23) | 3.75e-07 | phi | 2.064829 | 0.0016 |
| psi | 0.675325 | < 2.2e-16 | |||
| rho | −0.782638 | < 2.2e-16 | |||
| lambda | 0.897849 | < 2.2e-16 | |||
| Additive Model - Drugs | S.D. | 5.0551 | |||
| spreml(Cancer Rate ~ Age + Cigarettes + AUD + Cannabis + Analgesics + Cocaine | Log.Lik | − 2088.4810 | |||
| AUD | 30.08 (3.65, 56.51) | 0.02571 | phi | 2.045313 | 5.47e-05 |
| Cannabis | −1.54 (−3, −0.08) | 0.0384 | psi | 0.607328 | < 2.2e-16 |
| Age | −0.79 (− 1.13, − 0.46) | 3.50e-06 | rho | − 0.789941 | < 2.2e-16 |
| lambda | 0.878741 | < 2.2e-16 | |||
| Interactive Model - Drugs | S.D. | 5.0317 | |||
| spreml(Cancer Rate ~ Age + Cigarettes * AUD * Cannabis + Analgesics + Cocaine | Log.Lik | − 2090.8060 | |||
| Cannabis | −1.81 (−3.22, − 0.39) | 0.01231 | phi | 2.018035 | 0.0030 |
| Age | −0.9 (−1.21, − 0.59) | 1.81e-08 | psi | 0.61679 | < 2.2e-16 |
| rho | −0.792062 | < 2.2e-16 | |||
| lambda | 0.88467 | < 2.2e-16 | |||
| Interactive Model - Comprehensive | S.D. | 4.8427 | |||
| spreml(Cancer Rate ~ Age + Cigarettes * AUD * Cannabis + Analgesics + Cocaine + Income + Five Races) | Log.Lik | −2090.3930 | |||
| Age | −1 (−1.28, − 0.73) | 4.04e-13 | phi | 1.751775 | 0.0003 |
| Hispanic | −1.49 (− 2.56, − 0.42) | 0.006247 | psi | 0.63281 | < 2.2e-16 |
| rho | − 0.778829 | < 2.2e-16 | |||
| lambda | 0.88237 | < 2.2e-16 | |||
| Interactive Cannabinoid Model - Comprehensive | |||||
| spreml(Cancer Rate ~ Age + Cigarettes * THC * CBG * CBD + AUD + Income + Five Races) | |||||
| AUD | 36.55 (9.15, 63.96) | 0.0090 | S.D. | 5.1269 | |
| CBG | 2.18 (0.2, 4.16) | 0.0312 | Log.Lik | − 2079.543 | |
| THC: CBG: CBD | −5.19 (−8.32, − 2.06) | 0.0012 | phi | 2.152804 | 0.0015 |
| THC: CBD | −17.59 (−28.21, −6.97) | 0.0012 | psi | 0.579133 | < 2.2e-16 |
| THC: CBG | −21.24 (−33.23, −9.25) | 0.0005 | rho | −0.779342 | < 2.2e-16 |
| THC | −74.58 (−115.58, − 33.58) | 0.0004 | lambda | 0.862257 | < 2.2e-16 |
| Age | −0.84 (−1.24, − 0.43) | 4.61e-05 | |||