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. 2022 Mar 30;9(3):e1161. doi: 10.1212/NXI.0000000000001161

Figure 5. Siponimod Also Reduces Early Demyelination but Does Not Alter Oligodendrocyte Precursor Cell Survival.

Figure 5

Quantitative analysis of longitudinal sections of optic nerves of C57Bl/6J mice for (A) Olig2, (B) PDGFRα, and (C) MBP at 21 and 35 days after myelin oligodendrocyte glycoprotein fragment 35-55 immunization. Representative images of the stainings (D); dotted lines indicate areas of demyelination, scale bar = 50 µm. One optic nerve per mouse was included for histologic examination. All graphs represent the pooled mean ± SEM, and gray dots show individual data points (n = 6 animals per group out of 2 independent experiments), with *p < 0.05, **p < 0.01, and ***p < 0.001 by ANOVA with the Dunnett post hoc test compared with untreated myelin oligodendrocyte glycoprotein experimental autoimmune encephalomyelitis. §Few data points out of axis limits. ANOVA = analysis of variance.