Fig. 5.

Two exemplary applications of prime-seq. A Experimental design for an acute myeloid leukemia (AML) study, where a biopsy punch was used to collect a small fraction of a frozen patient-derived xenograft (PDX)-AML sample. B Prime-seq libraries were generated from 94 PDX samples, derived from 11 different AML-PDX lines (color-coded) from 5 different AML subtypes (symbol-coded) and cluster primarily by AML subtype. C Experimental design for studying the differentiation from five human-induced pluripotent stem cell lines (iPSCs) to neural progenitor cells (NPC). D Expression levels from 20 a priori known marker genes cluster iPSCs and NPCs as expected