Table 1.
A Variety of Stem Cells Technologies Provide the Promise for Curing Reproductive Diseases.
| Gender | Organs | Infertility diseases | Stem cells types | Applications | Effects and reference |
|---|---|---|---|---|---|
| Male | Testis | Azoospermia Apsermia Oligospermia Varicocele |
ADSCs | Rat | Spermatogenesis↑, Testis morphology↑, Birth↑ 5 |
| UCSCs | Mouse | Germ cells↑, Testicular tissue↑ 6 | |||
| iPSCs | Human | Spermatogenesis↑ 7 | |||
| SSCs | Macaque | Spermatogenesis↑ 8 | |||
| Asthenozoospermia | UCSCs | Hypothesis | Germ cells↑ 6 | ||
| Female | Endometrium | Asherman’s syndrome | MenSCs | Human | Endometrium↑ 9 |
| Intrauterine adhesions | UCSCs | Human | Endometrium↑, Birth↑ 4 | ||
| Thin endometrium and recurrent pregnancy losses | EPCs | Mouse | Endometrium↑, Birth↑ 10 | ||
| Ovary | Polycystic Ovarian Syndrome | ADSCs | Mouse, Rat | Follicles↑, Estradiol↑ 11 | |
| Premature Ovarian Failure | AFSCSs | Mouse | Follicles↑ 12 | ||
| Premature Ovarian Failure | BMSCS | Mouse | Follicles↑, Follicular stimulated hormone↓, Estradiol↑ 13 | ||
| Premature Ovarian Failure | OSCs | Mouse | Oocytes↑, Birth↑14,15 | ||
| Premature Ovarian Failure | ESCs | Mouse | Oocytes↑14,16 |
ADSCs: adipose tissue-derived MSCs; AFSCs: amniotic fluid stem cells; iPSCs: induced pluripotent stem cells; menSCs: menstrual blood-derived stromal cells; OSCs: oogonial stem cells; SSCs: spermatogonial stem cells; UCSCs: umbilical cord stem cells; BMSCs: bone marrow stem cells; EPCs: endometrial progenitor cells; ESCs: embryonic stem cells.