Figure 6.

S-MGB-364 and NIV encapsulation did not affect pulmonary histopathology. C57BL/6 mice (n = 6 per group) were infected with 100 cfu of Mtb HN878 strain via intranasal challenge. At 1, 2, 3 and 4 weeks post-infection, mice were intranasally treated with 10 mg/kg of S-MGB-364, S-MGB-364-NIV, or saline. Mice were sacrificed at 5 weeks post-infection and lungs were collected in 4% formalin for histopathology analysis. Percentage of (a) alveolar space, (b) iNOS, (c) CD3, (d) Arg1, and (e) MPO. Data show mean ± SEM. Scale bars represent 1000 μm. Magnification = 20×.