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. 2022 Jan 28;77(4):880–902. doi: 10.1093/jac/dkab505

Table 1.

Chemical name and structure, and mechanism of action of delamanid and pretomanid

Characteristic Delamanid (OPC-67683) Pretomanid (PA-824)
Developed by: Otsuka Pharmaceutical Co., Ltd. PathoGenesis Corporation
Chemical namea: (2R)-2-methyl-6-nitro-2-[(4-{4-[4-(trifluoromethoxy)phenoxy] piperidin-1-yl}phenoxy)methyl]-2,3-dihydroimidazo[2,1-b][1,3]oxazole (6S)-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
Chemical structurea graphic file with name dkab505il1.jpg graphic file with name dkab505il2.jpg
Mechanism of action 1. Inhibition of mycolic acid synthesis (methoxymycolates and ketomycolates) 1. Inhibition of mycolic acid synthesis (ketomycolates)
2. Respiratory poisoning (reactive intermediates are yet to be identified) 2. Respiratory poisoning by the release of reactive nitrogen species upon metabolic activation
a

Information extracted from https://pubchem.ncbi.nlm.nih.gov.