Table 2.
Primary and Secondary Outcomes.
| Outcome | rTMS group (n = 20) | sham group (n = 19) | Cohen’s d (rTMS to sham at 3 weeks) | P value | ||||
|---|---|---|---|---|---|---|---|---|
| Baseline | 3 Weeks | Change From Baseline | Baseline | 3 Weeks | Change From Baseline | |||
| Primary outcome | ||||||||
| NRS | 6.5 (1.7) | 3.8 (1.4) | -2.7 (1.2) | 6.4 (1.6) | 4.9 (1.2) | -1.5 (1.3) | -0.822 | 0.017 |
| Secondary Outcome | ||||||||
| OME daily dose, mg | 109.5(52.5) | 111.5(52.5) | 2.0 (12.5) | 111.8(59.7) | 157.9(84.3) | 42.1 (31.7) | -0.603 | 0.05 |
| WHOQOL-BREF domain | ||||||||
| Physiology | 47.9 (15.9) | 66.3 (16.3) | 15.8 (13.9) | 49.4 (15.5) | 55.1 (11.4) | 8.3 (9.5) | 0.796 | 0.02 |
| Psychology | 52.4 (14.3) | 69.7 (14.9) | 12.6 (7.4) | 53.2 (16.1) | 59.7 (11.7) | 8.1 (5.5) | 0.746 | 0.031 |
| Social relationship | 57.1 (15.1) | 72.0 (13.1) | 12.4 (10.2) | 57.8 (15.5) | 70.1 (11.4) | 10.9 (2.0) | 0.155 | 0.638 |
| Environment | 53.9 (14.9) | 66.9 (15.1) | 11.8 (8.9) | 55.5 (14.9) | 64.9 (12.2) | 8.9 (10.6) | 0.146 | 0.654 |
| HAM-A | 13.3 (6.5) | 9.1 (3.9) | -4.2(3.5) | 13.6 (5.7) | 13.2 (4.5) | -0.5 (2.8) | -0.949 | 0.005 |
| HAM-D | 14.1 (5.9) | 9.9 (3.6) | -4.2(2.9) | 14.3 (5.4) | 13.2 (4.2) | -1.1(2.1) | -0.869 | 0.011 |
Data given as mean (SD) NRS, numeric rating scale; OME, oral morphine equivalent; SD, standard deviation; WHOQOL-BREF, World Health Organization Quality of Life-BREF; HAM-A, Hamilton Anxiety Scale; HAM-D, Hamilton Depression Scale.