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. 2022 Mar 17;12:859621. doi: 10.3389/fonc.2022.859621

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Copyright © 2022 Xu, Zhang, Chen, Xu, Luo, Yan, Lu, Liu, Ou, Tan, Liang, Chen, Song and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sev upregulated ferroptosis-associated gene ATF4 in glioma cells. (A) Representative GSEA plot depicting ferroptosis involved in Sev-treated U251 cells. (B) Representative GSEA plot depicting mitophagy involved in Sev-treated U251 cells. (C) A heat map showing the upregulated and downregulated genes involved in ferroptosis and mitophagy in Sev-treated U251 cells compared to the control. Each row corresponds to a RNA, each line to a sample. Higher expression level is indicated by yellow, and lower level is indicated by blue. (D) The mRNA levels of ATF4 in Sev-treated U87 and U251 cells were detected by qRT-PCR. (E) The protein level of ATF4 in Sev-treated U87 and U251 cells was detected by Western blotting. Data were expressed as mean ± standard deviation. *p < 0.05, **p < 0.01, compared with control, GAPDH is used as internal control.