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. 2022 Mar 17;13:778221. doi: 10.3389/fphar.2022.778221

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Copyright © 2022 Yang, Geng, You, Yuan, Meng, Ma, Gu and Lei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The protein expression of p-JAK2, JAK2, p-STAT3 and STAT3 in the AR42J cell model was measured by western blot. (A,B) p-JAK2 and JAK2 protein expression in the control, cerulein, rhein 0.25 μg/ml, rhein 0.5 μg/ml and rhein 1 μg/ml groups. (C,D) p-STAT3 and STAT3 protein expression in the control, cerulein, rhein 0.25 μg/ml, rhein 0.5 μg/ml and rhein 1 μg/ml groups. Data are expressed as mean ± SD (n = 5 per group). Significance between groups was evaluated by one way analysis of variance (ANOVA) followed by a Tukey post hoc test. *p < 0.05, **p < 0.01 and ***p < 0.001 compared with the control group; ^# p < 0.05, ^## p < 0.01 and ^### p < 0.001 compared with the cerulein group; ^$ p < 0.05, ^$$ p < 0.01 and ^$$$ p < 0.001 compared with the rhein 0.25 μg/ml group. JAK2, janus kinase two; STAT3, signal transducer and activator of transcription 3.