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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Life Sci. 2022 Mar 1;296:120444. doi: 10.1016/j.lfs.2022.120444

Figure 2. Effect of angiotensin II on NKA α1 expression and activity in WT and PPAR-α KO mice:

Figure 2

A, Representative western blot of NKA α1 (upper panel) and β-actin bottom panel is shown in membrane-enriched kidney cortex samples from WT and PPARα KO mice treated as vehicle (−) or with angiotensin II (+) infusion by osmotic minipump for 12 days. Gel was loaded with an equivalent amount of protein from each mouse kidney. B, density summary of NKA α1; and summary of NKA α1 densitometry (mean ± sem, n = 6/group); results of two-way ANOVA (genotype X treatment) displayed in graph insets. Significant effect (p < 0.05) shown in bold font. C, summary of Na+-K+ ATPase activity (mean ± sem, n = 6/group); results of two-way ANOVA (genotype X treatment). D, summary of NKA mRNA levels by qRT-PCR. Significant effect (p < 0.05) shown in bold font.