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In vivo PK profile of 31 following a single i.p. dose at 10 mg/kg to male Sprague-Dawley rats
| Cmax (ng/mL) | tmax (h) | CL_F (mL/min/kg) |
AUCinf (ng/mL*h) |
Half-life t1/2 (h) |
|
|---|---|---|---|---|---|
| Plasma | 288.4 | 0.4 | 240.6 | 715.2 | 0.63 |
| Brain | 594.6 | 0.4 | 120.7 | 1438.2 | 0.90 |
|
Kp (Brain/plasma ratio) |
2.0 |
