Figure 3. Basal systolic, diastolic, and mean arterial pressure and their responses to Ang II infusion with or without concurrent treatment with losartan in adult male and female wildtype and proximal tubule-specific PT-Agtr1a^−/− mice.

Comaprisons of basal systolic (A,D), diastolic (B,E) and mean arterial blood pressure (C,F) and their responses to Ang II infusion with or without AT₁ (AT_1a) receptor blocker losartan between male and female WT and PT-Agtr1a^−/− mice. Proximal tubule-specific deletion of AT_1a receptors significantly decreased basal blood pressure by ~13–15 ± 3 mmHg similarly in male and female PT-Agtr1a^−/−mice under basal conditions, and significantly atteuated the hypertensive responses to Ang II in both male and female PT-Agtr1a^−/−mice. No sex differences were found in basal blood pressure and its responses to Ang II with or without losartan treatment between male and female WT or between male and female PT-Agtr1a^−/− mice. *P<0.05 or **P<0.01 vs. control WT or PT-Agtr1a^−/− mice; ⁺P<0.05 or ⁺⁺P<0.01 vs. Ang II-infused male or female WT or PT-Agtr1a^−/− mice.