Figure 5. Comaprisons of basal 24-h urinary Na⁺, K⁺, Cl⁻ excretion and their responses to Ang II-induced hypertension treated with or without the AT₁ receptor blocker losartan between male and female WT and PT-Agtr1a^−/− mice.

The data were normalized by the kidney weight for comparisons of gender differences. Note that basal 24-h urinary Na⁺ and K⁺ excretion were significantly higher in male and female PT-Agtr1a^−/− mice than their male and female WT mice. However, basal 24 h urinary Na⁺ and K⁺ excretion were lower in female than male WT and PT-Agtr1a^−/− mice. These natriuretic and kaliuric responses to Ang II-induced hypertension were moderately augmented in male but blunted in female PT-Agtr1a^−/− mice. *P<0.05 vs. basal WT or PT-Agtr1a^−/− controls. ^&P<0.05 vs. wildtype basal.