Table 1.

The expression levels of AT_1a, AT_1b, and AT₂ receptors in the superficial cortex of the kidney in male and female WT littermates and PT-Agtr1a^−/− mice (n=10 each strain, 5 males and 5 females)

Parameter	WT littermate	PT-Agtr1a−/−
AT1a mRNA, copy/ng RNA	652.9 ± 33.8	54.6 ± 4.52
AT1b mRNA, copy/ng RNA	1.3 ± 0.091	0.94 ± 0.051
AT2 mRNA, copy/ng RNA	0.17 ± 0.011	0.15 ± 0.011

¹P<0.01 vs. AT_1a.

²P<0.01 vs. WT littermate.

Note that AT_1a mRNA expression in PT-Agtr1a^−/− mice was assayed from freshly isolated proximal tubules, and that AT_1b or AT₂ expression was not significantly up-regulated or increased in the superficial cortex of the kidney in PT-Agtr1a^−/− mice.