Table 2.

Basal general physiological phenotypes of control adult male and female WT and proximal tubule-specific PT-Agtr1a^−/− mice

Parameter	WT male (n=8)	PT-Agtr1a−/− male (n=10)	WT female (n=16)	PT-Agtr1a−/− female (n=10)
Body wt., g	26 ± 0.5	26 ± 0.5	21 ± 0.63,4	24 ± 0.91
Heart wt., g	0.18 ± 0.01	0.13 ± 0.012	0.14 ± 0.013,4	0.12 ± 0.01
Heart wt./body wt. ratio	0.62 ± 0.2	0.52 ± 0.012	0.66 ± 0.03	0.53 ± 0.022
Left kidney wt., g	0.18 ± 0.01	0.18 ± 0.01	0.14 ± 0.013,4	0.14 ± 0.011,3,4
Left kidney wt./body wt. ratio	0.68 ± 0.05	0.68 ± 0.03	0.67 ± 0.02	0.61 ± 0.12,3,4
Blood volume, mL.	0.64 ± 0.03	0.66 ± 0.04	0.61 ± 0.06	0.58 ± 0.033,4
Hematocrit, %	48.0 ± 0.9	47.0 ± 0.5	50.0 ± 0.5	46.0 ± 0.52
Fluid intake, ml/24 h	3.0 ± 0.16	2.8 ± 0.4	3.4 ± 0.2	2.2 ± 0.32
Urine volume, ml/24 h	1.2 ± 0.15	1.1 ± 0.05	0.74 ± 0.133,4	0.77 ± 0.143,4
Urine Na+ conc., mmol/l	196 ± 30	199 ± 12	102 ± 123,4	107 ± 153,4
Urine K+ conc., mmol/l	278 ± 26	285 ± 25	174 ± 203,4	151 ± 233,4
Urine Cl− conc., mmol/l	235 ± 37	257 ± 19	151 ± 223,4	163 ± 223,4

¹P<0.05 or

²P<0.01 vs. male or female WT mice.

³P<0.05 or

⁴P<0.01 vs. male WT or PT-Agtr1a^−/− mice, respectively.