Table 3.

General phenotypic responses to Ang II-induced hypertension (1.5 mg/kg/day, i.p.) for 2 weeks in adult male and female WT and proximal-tubule specific PT-Agtr1a^−/− mice

Parameter	WT male + Ang II (n=9)	PT-Agtr1a−/− male + Ang II (n=9)	WT female + Ang II (n=8)	PT-Agtr1a−/−female + Ang II (n=10)
Body wt., g	23.0 ± 0.5	26.0 ± 0.6	20.0 ± 0.83	22.0 ± 0.43
Heart wt., g	0.17 ± 0.03	0.18 ± 0.01	0.14 ± 0.013	0.14 ± 0.013
Heart wt./body wt. ratio	0.76 ± 0.04	0.74 ± 0.04	0.79 ± 0.03	0.70 ± 0.023
Left kidney wt., g	0.15 ± 0.02	0.17 ± 0.01	0.13 ± 0.01	0.14 ± 0.063
Left kidney wt./body wt. ratio	0.68 ± 0.03	0.70 ± 0.01	0.77 ± 0.044	0.72 ± 0.04
Blood volume, ml	0.54 ± 0.04	0.56 ± 0.05	0.53 ± 0.03	0.59 ± 0.041,3
Hematocrit, %	54 ± 0.7	50 ± 1.31	50 ± 1.43	49 ± 1
Fluid intake, ml/24 h	4.6 ± 0.3	5.7 ± 0.62	4.9 ± 0.5	4.6 ± 0.24
Urine volume, ml/24 h	2.3 ± 0.2	1.9 ± 0.2	2.0 ± 0.2	1.5 ± 0.23
Urine Na+ conc., mmol/l	194 ± 15	244 ± 241	173 ± 21	236 ± 452
Urine K+ conc., mmol/l	262 ± 28	285 ± 25	273 ± 25	385 ± 752,4
Urine Cl− conc., mmol/l	298 ± 18	294 ± 44	237 ± 26	319 ± 872

¹P<0.05 or

²P<0.01 vs. male or female WT mice.

³P<0.05 or

⁴P<0.01 vs. male WT or PT-Agtr1a^−/− mice, respectively.