Table 4.

General phenotypic responses to Ang II-induced hypertension (1.5 mg/kg/day, i.p.) treated with the AT₁ receptor blocker losartan (20 mg/kg/day, p.o.) for 2 weeks in adult male and female WT and proximal-tubule specific PT-Agtr1a^−/− mice

Parameter	WT male + Ang II + Los (n=9)	PT-Agtr1a−/− male + Ang II + Los (n=9)	WT female + Ang II + Los (n=9)	PT-Agtr1a−/− female + Ang II + Los (n=10)
Body wt., g	27 ± 0.5	28 ± 0.7	22 ± 0.52,4	23 ± 0.44
Heart wt., g	0.20 ± 0.01	0.19 ± 0.01	0.15 ± 0.012,4	0.13 ± 0.014
Heartwt./body wt. ratio	0.79 ± 0.01	0.71 ± 0.042	0.75 ± 0.013	0.62 ± 0.032,4
Left kidney wt., g	0.20 ± 0.03	0.18 ± 0.01	0.14 ± 0.021,4	0.15 ± 0.014
Left kidney wt./body wt. ratio	0.76 ± 0.03	0.70 ± 0.032	0.72 ± 0.02	0.70 ± 0.01
Blood volume, ml	0.77 ± 0.05	0.68 ± 0.022	0.56 ± 0.034	0.61 ± 0.021,4
Hematocrit, %	48.0 ± 0.7	48.0 ± 1.1	50.0 ± 1.1	47.0 ± 0.8
Fluid intake, ml/24 h	3.0 ± 0.4	3.2 ± 0.4	3.3 ± 0.3	3.4 ± 0.4
Urine volume, ml/24 h	1.5 ± 0.1	1.3 ± 0.1	0.68 ± 0.12,4	0.80 ± 0.12,4
Urine Na+ conc., mmol/l	248 ± 24	223 ± 23	159 ± 142,4	203 ± 262
Urine K+ conc., mmol/l	299 ± 23	296 ± 32	208 ± 324	277 ± 362
Urine Cl− conc., mmol/l	303 ± 27	290 ± 33	270 ± 44	261 ± 59

¹P<0.05; or

²P<0.01 vs. male or female WT mice.

³P<0.05 or

⁴P<0.01 vs. male WT or PT-Agtr1a^−/− mice, respectively.