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. Author manuscript; available in PMC: 2023 Mar 9.
Published in final edited form as: J Am Chem Soc. 2022 Mar 1;144(9):3833–3842. doi: 10.1021/jacs.1c10621

Figure 1. Exploring the O-GlcNAc-dependant meltome.

Figure 1.

a) Installation of O-GlcNAc on proteins by OGT and its removal by OGA can each be antagonized within cells using the small molecule inhibitors 5SG and TMG, respectively. b) Hypothesis that O-GlcNAc stabilizes proteins against thermal unfolding. Abbreviations: 5SG; 2-acetamido-2-deoxy-5-thio-α-D-glucopyranose, TMG; Thiamet-G, OGA; O-GlcNAc hydrolase, OGT; O-GlcNAc transferase.