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. 2022 Mar 17;12:861078. doi: 10.3389/fonc.2022.861078

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Copyright © 2022 Tirrò, Massimino, Broggi, Romano, Minasi, Gianno, Antonelli, Motta, Certo, Altieri, Manzella, Caltabiano, Barbagallo, Buttarelli, Magro, Giangaspero and Vigneri

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Detection of ATRX loss by immunohistochemistry and NGS. (A) Retained nuclear expression of ATRX in neoplastic glioma cells (immunoperoxidase; original magnification 200x). (B) Loss of nuclear expression of ATRX in a sample of astrocytoma (case 49) (left panel). Note the retained immunoreactivity in endothelial cells and non-neoplastic entrapped glial cells (immunoperoxidase; original magnification 200x). NGS demonstrated the presence of the ATRX p. Lys329IlefsTer3 truncated mutation (case 49) (right panel). Results were viewed in the IGV.