Skip to main content
. 2022 Mar 17;16:838122. doi: 10.3389/fnbeh.2022.838122

FIGURE 1.

FIGURE 1

Baseline despair-like behaviors in adult C57BL/6N, DBA/2, and FVB/N mice. (A) In the tail suspension test, adult C57BL/6N mice exhibited a higher duration of baseline immobility than DBA/2 and FVB/N mice. (B) Adult DBA/2 mice showed a significantly increased latency to first immobility compared to C57BL/6N and FVB/N mice. In the forced swim test, adult C57BL/6N mice showed a higher immobility duration (C), a lower latency to first immobility (D) and a lower total traveled distance (E) than DBA/2 and FVB/N mice. In panels (A–E), male and female mice within the aforementioned strains showed similar performance in the tail suspension and forced swim tests. Blue and red dots represent males and females, respectively. Two-way ANOVA was used followed by the Tukey’s post-hoc test for multiple comparisons to determine differences between the three strains, C57BL/6N, DBA/2, and FVB/N (**p ≤ 0.01, ***p ≤ 0.001) and Bonferroni correction to check differences between males and females within each strain. Error bars indicate the standard error of the mean (SEM).