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. 2022 Mar 17;12:818001. doi: 10.3389/fonc.2022.818001

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Copyright © 2022 Lin, Zhang, Arroyo, Singal, Parikh and Lubman

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fucosylation ratio of glycopeptide (A) ELHHLQEQN⁷⁶²VSNAFLDK_HexNAc(5)Hex(6)Fuc(2)NeuAc(3)of ceruloplasmin in cirrhosis and early stage HCC serum samples. (B) Two-dimensional plot of AFP and fucosylation ratio of this glycopeptide between cirrhosis and HCC samples. (C) ROC analysis of glycopeptide in combination with AFP in distinguishing HCC from cirrhosis.