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. 2022 Mar 17;12:818001. doi: 10.3389/fonc.2022.818001

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Copyright © 2022 Lin, Zhang, Arroyo, Singal, Parikh and Lubman

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative MS/MS spectrum of N-glycopeptide of ELHHLQEQN⁷⁵⁶VSNAFLDK with the glycan HexNAc(5)Hex(6)Fuc(2)NeuAc(3). The oxonium ions, glycosidic fragments and b/y fragments from the peptide backbone were well characterized. Specific diagnostic fragment ion (HexNac+Gal+Fuc) at m/z 512.20 confirmed the outer-arm fucosylation, and ions (pep+HexNac+Fuc) at m/z 1186.08 and (pep+2HexNac+Fuc) at m/z 1287.61 (marked by red dashed rectangles) confirmed the core-fucosylation. (The symbols used in the structural formulas: blue square = HexNAc; green circle = Man; yellow circle = Gal; purple diamond = NeuAc).