TABLE 3.
The average changes of metabolites (VIP>1) in plasma contributing to discrimination between P group and H + P or Sham group in PLS-DA models (Mean ± SD).
| Metabolites | VIP value | H + P/P | Sham/P |
|---|---|---|---|
| LysoPC(18:1 (11Z)) | 8.7538 | 109.87 ± 33.22↑ | 197.17 ± 67.06↑ |
| SM(d18:0/16:1 (9Z)) | 4.8505 | 54.61 ± 12.07 | 66.04 ± 7.89 |
| (7S,8S)-DiHODE | 4.5799 | 1.45 ± 0.95 | 13.21 ± 29.05 |
| PC(16:1 (9Z)/20:3 (8Z,11Z,14Z)) | 3.8339 | 71.35 ± 4.49 | 70.49 ± 24.6 |
| PC(18:0/20:4 (8Z,11Z,14Z,17Z)) | 3.5755 | 79.71 ± 16.44 | 72.6 ± 13.99 |
| 9Z,12Z,15Z)-(7S,8S)-Dihydroxyoctadeca-9,12,15-trienoic acid | 3.4277 | 2.26 ± 1.9 | 16.36 ± 38.53 |
| SM(d18:1/16:0) | 3.2129 | 54.72 ± 12.42 | 65.97 ± 8.35 |
| L-Leucine | 2.9912 | 71.56 ± 29.07 | 42.1 ± 16.1 |
| SM(d18:1/22:0) | 2.3943 | 12,414.9 ± 7,455.65↑ | 29,165.99 ± 3,567.52↑ |
| L-Acetylcarnitine | 2.2603 | 64.79 ± 51.66 | 45.15 ± 28.72 |
| LysoPC(16:1 (9Z)) | 2.1503 | 120.16 ± 48.19↑ | 194.67 ± 87.07↑ |
| PC(14:0/22:1 (13Z)) | 2.1434 | 158.9 ± 45.95↑ | 131.21 ± 27.05↑ |
| Phytosphingosine | 1.9513 | 39.7 ± 17.08 | 73.56 ± 19.06 |
| SM(d18:0/24:1 (15Z)) | 1.9409 | 238,784.35 ± 16,798.01↑ | 224,709.69 ± 51,002.03↑ |
| LysoPC(20:3 (5Z,8Z,11Z)) | 1.9336 | 124.21 ± 44.74↑ | 234.11 ± 81.87↑ |
| Valerylcarnitine | 1.8434 | 21.37 ± 41.91 | 4.55 ± 3.63 |
| PC(16:1 (9Z)/22:5 (7Z,10Z,13Z,16Z,19Z)) | 1.8362 | 96.12 ± 11.15 | 67.12 ± 22.14 |
| L-Carnitine | 1.8091 | 107.89 ± 66.08↑ | 154.27 ± 122.87↑ |
| PC(18:1 (9Z)/20:4 (5Z,8Z,11Z,14Z)) | 1.808 | 88.54 ± 4.69 | 80.66 ± 16.74 |
| Linoleic acid | 1.6941 | 79.54 ± 52.93 | 58.38 ± 66.65 |
| 2-Hydroxybutanoic acid | 1.6393 | 78.68 ± 23.79 | 54.8 ± 22.73 |
| Linoleyl carnitine | 1.597 | 25.31 ± 32.4 | 13.39 ± 11.23 |
| LysoPC(20:2 (11Z,14Z)) | 1.579 | 130.59 ± 40.76↑ | 229.5 ± 90.19↑ |
| Hypoxanthine | 1.5743 | 81.07 ± 121.41 | 332.17 ± 485.44↑ |
| (9Z)-(7S,8S)-Dihydroxyoctadecenoic acid | 1.5368 | 4.24 ± 1.78 | 9.27 ± 16.36 |
| Hexadecasphinganine | 1.5018 | 104.14 ± 29.52↑ | 80.52 ± 73.25 |
| L-Valine | 1.4966 | 76.8 ± 28.95 | 85.28 ± 31.63 |
| Propionylcarnitine | 1.4793 | 31.05 ± 59.64 | 13.22 ± 13.6 |
| Chenodeoxycholic acid | 1.4612 | 46.59 ± 80.13 | 31.65 ± 29.27 |
| L-Proline | 1.4518 | 83.38 ± 39.72 | 155.89 ± 22↑ |
| PC(18:2 (9Z,12Z)/P-18:1 (9Z)) | 1.4426 | 70.52 ± 12.35 | 51.71 ± 10.66 |
| 11Z-Octadecenylcarnitine | 1.3778 | 29.63 ± 19.96 | 25.66 ± 13.56 |
| Lactic acid | 1.328 | 76.2 ± 89.3 | 93.93 ± 91.29 |
| isocitric acid | 1.2934 | 106.34 ± 54.33↑ | 155.03 ± 39.4↑ |
| SM(d18:1/20:0) | 1.2732 | 395.62 ± 392.34↑ | 853.05 ± 512.89↑ |
| Arachidonic acid | 1.2628 | 76 ± 43.85 | 39.16 ± 33.48 |
| Niacinamide | 1.249 | 90.59 ± 64.88 | 48.99 ± 13.67 |
| PC(14:0/22:0) | 1.2306 | 176.7 ± 79.76↑ | 146.02 ± 32.71↑ |
| SM(d18:1/18:1 (11Z)) | 1.1903 | 41.67 ± 9.75 | 60.37 ± 17.48 |
| Sphingosine 1-phosphate | 1.175 | 135.9 ± 36.87↑ | 228.98 ± 127.85↑ |
| PC(o-16:1 (9Z)/18:0) | 1.1643 | 203.38 ± 75.24↑ | 176.82 ± 91↑ |
| SM(d18:0/18:1 (11Z)) | 1.1307 | 77.2 ± 18.12 | 69.39 ± 24.83 |
| SM(d18:1/24:0) | 1.1032 | 11,122.94 ± 656.4↑ | 8,706.75 ± 2,919.36↑ |
| LysoPC(14:0) | 1.1012 | 101.44 ± 60.3↑ | 244.67 ± 184.72↑ |
| PC(o-18:1 (9Z)/20:4 (8Z,11Z,14Z,17Z)) | 1.0912 | 79.45 ± 8.38 | 63.32 ± 14.59 |
| succinic acid | 1.0772 | 64.08 ± 115.03 | 17.72 ± 15.59 |
| SM(d18:1/22:1 (13Z)) | 1.0645 | 200.5 ± 70.03↑ | 207.66 ± 59.26↑ |
| PC(14:0/22:5 (4Z,7Z,10Z,13Z,16Z)) | 1.0426 | 76.11 ± 15.64 | 82.2 ± 26.1 |
| PC(o-16:1 (9Z)/18:2 (9Z,12Z)) | 1.0415 | 64.27 ± 11.47 | 56.95 ± 5.5 |
| Uric acid | 1.036 | 77.53 ± 93.78 | 15.96 ± 10.2 |
| Vaccenic acid | 1.0322 | 74.45 ± 46.36 | 74.33 ± 102.24 |
| Sphinganine | 1.0199 | 64.08 ± 12.87 | 80.79 ± 36.63 |
Arrow indicates significantly up-regulated, but no arrow down-regulated metabolites in the H + P and sham groups compared with P group, each group n = 6.