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. 2022 Mar 17;13:832937. doi: 10.3389/fneur.2022.832937

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Copyright © 2022 Masakado, Kagaya, Kondo, Otaka, Dekundy, Hanschmann, Geister and Kaji.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Response rates (%) for at least 1-point improvement from baseline in MAS-PF at Weeks 4, 6, and 8 in the MP and at the Week 4 assessment visit during Cycles 2, 3, and 4 in the OLEX (worst-case approach, FAS). Comparisons between treatment groups were performed using a logistic regression model where response to treatment was the dependent variable, baseline MAS-PF score was a covariate, and site (pooled), treatment and sex were factors. CI, confidence interval; FAS, full analysis set; MAS-PF, Modified Ashworth Scale spasticity score for the plantar flexors; MP, main period; OLEX, open-label extension period; OR, odds ratio. *p < 0.05. **p < 0.01.