Anti-CD45 immunohistochemistry is reduced after rAAV-sFKN treatment. Anti-CD45 staining of rAAV-GFP (A) and rAAV-sFKN (B) -injected mice hippocampi (scale = 200 μm). Morphology of CD45-stained cells in an rAAV-GFP injected mouse (scale = 50 μm) (C). Percentage area positive staining for anti-CD45 (D). * P < 0.02. Abbreviations: AAV, adeno-associated virus serotype; FKN, fractalkine; GFP, green fluorescent protein; rAAV, recombinant AAV; sFKN, secreted FKN.