TABLE 2.
Final consensus: consensus achieved for 92 itemsa
| RDoC | MADRS | HAM-D17 | IDS-SR | HAM-A | PANSS |
|---|---|---|---|---|---|
| Negative valence systems | 1. Apparent sadness 2. Reported sadness 3. Inner tension 10. Suicidal thoughts |
1. Depressed mood 10. Anxiety (psychic) 11. Anxiety (somatic)b 15. Hypochondriasis |
5. Feeling sad 6. Feeling irriatable 7. Feeling anxious or tense 18. Thoughts of death or suicide |
1. Anxious mood 3. Fears 6. Depressed mood |
G2. Anxiety G6. Depression |
| Positive valence systems | 8. Inability to feel | 7. Work and activities 14. Genital symptoms |
8. Response of your mood to good or desired events 21. Capacity for pleasure or enjoyment (excluding sex) |
17. View of my future 19. General interest 22. Interest in sex (interest, not activity) |
N/A |
| Cognitive systems | 6. Concentration difficulties | 2. Feelings of guilt 16. Insight |
15. Concentration/decision making | 5. Intellectual | P1. Delusions P2. Conceptual disorganization P3. Hallucinatory behavior P5. Grandiosity P6. Suspiciousness/persecution N5. Difficulty in abstract thinking N6. Lack of spontaneity and flow of conversation N7. Stereotyped thinking |
| Social processes | N/A | N/A | 16. View of myself 29. Interpersonal sensitivity |
N/A | P7. Hostility N1. Blunted affectb N3. Poor rapport N4. Passive/apathetic social withdraw |
| Arousal/regulatory systems | 4. Reduced sleep 5. Reduced appetite |
4. Insomnia (early in the night) 5. Insomnia (middle of the night) 6. Insomnia (early hours of the morning) 9. Agitation 15. Hypochondriasisb 16. Loss of weight |
1. Falling asleep 2. Sleep during the night 3. Waking up too early 4. Sleeping too much 9. Mood in relation to time of day |
11. Decreased appetite 12. Increased appetite 13. Decreased weight 14. Increased weight 20. Energy level 24. Feeling restless |
2. Tension 4. Insomnia 9. Cardiovascular symptoms 13. Autonomic symptoms 14. Behavior at interviewb |
| Sensorimotor systems | 7. Lassitude | 8. Retardation 15. Hypochondriasisb |
23. Feeling slowed down 30. Leaden paralysis/physical energy |
14. Behavior at interviewb | G5. Mannerisms and posturing |
aItems featured in this table consist of all line items for which consensus was reached from 5 out of 7 clinical scales assessed during the live advisory board (line items are organized by the primary domain to which they have been allocated).
bLine item corresponding to two co-primary domains due to equal votes during the individual ranking segment of the live advisory board meeting HAM-A: Hamilton Anxiety Rating Scale; HAM-D17: 17-item Hamilton Depression Rating Scale; IDS-SR: Inventory of Depressive Symptomatology, Self-Report; MADRS: Montgomery-Asberg Depression Rating Scale; PANSS: Positive and Negative Syndrome Scale; RDoC: Research Domain Criteria; N/A: not applicable