TABLE 2.
Comparison of ABT-773 MICs for isolates of S. pneumoniae by erythromycin categoriesa
| MIC (μg/ml) | No. of strains | No. of strains (%) for which erythromycin MIC (μg/ml) is:
|
||
|---|---|---|---|---|
| ≤0.5 | 1–32 | ≥64 | ||
| ≤0.008 | 1,318 | 1,263 (95.8) | 40 (3.0) | 15 (1.1) |
| 0.015 | 99 | 29 (29.3) | 44 (44.4) | 26 (26.3) |
| 0.03 | 79 | 2 (2.5) | 62 (78.5) | 15 (19.0) |
| 0.06 | 48 | 4 (8.3) | 34 (70.8) | 10 (20.8) |
| 0.12 | 41 | 1 (2.4) | 33 (80.5) | 7 (17.1) |
| 0.25 | 13 | 8 (61.5) | 5 (38.5) | |
| 0.5 | 3 | 1 (33.3) | 2 (66.7) | |
a
Strains for which erythromycin MIC is ≤0.5 μg/ml are erythromycin susceptible or intermediate; strains for which erythromycin MIC is 1 to 32 μg/ml and clindamycin MIC is ≤0.25 have the efflux phenotype; strains for which erythromycin MIC is ≥64 μg/ml and clindamycin MIC is ≥8 μg/ml have the ermAM genotype.