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Reagents and conditions: (a) o-tolylboronic acid, Pd(PPh3)4, K2CO3, toluene/H2O, 110 °C, 75%; (b) NaOH, THF/H2O, RT, 95%; (c) tert-butyl 3-(methylamino)propanoate, NEt3, MeOH, RT; (d) NH2OH·HCl, NaHCO3, MeOH, reflux, 55% for 2 steps; (e) EDCI, HOBt, DMF, RT, 56%; (f) KOH (5 M), DMSO, RT, 82%.
